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Article

Is Bicuspid Aortic Valve Morphology Genetically Determined? A Family-Based Study.

The American journal of cardiology - 15 Jan 2022

Tessler Idit, Goudot Guillaume, Albuisson Juliette, Reshef Noga, Zwas Donna R, Carmi Shai, Shpitzen Shoshana, Levin Galina, Kelman Guy, Cheng Charles, Mazzella Jean-Michaël, Levin Yonatan, Messas Emmanuel, Gilon Dan, Durst Ronen

Abstract excerpt

Bicuspid aortic valve (BAV) is a common congenital heart disease, with a 10-fold higher prevalence in first-degree relatives. BAV has different phenotypes based on the morphology of cusp fusion. These phenotypes are associated with different clinical courses and prognoses. Currently, the determinants of the valve phenotype are unknown. In this study we evaluated the role of genetics using familial cohorts....

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PMID: 34799086
DOI: 10.1016/j.amjcard.2021.09.051

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