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Article

Genetic regulation of fasting-induced longevity effects.

Genetics - 6 May 2026

Luciano Alison, Robinson Laura, Schott William H, West A Phillip, Korstanje Ron, Churchill Gary A

Abstract excerpt

Dietary interventions such as caloric restriction and periodic fasting improve metabolic health and extend lifespan in preclinical models, yet individuals differ widely in their physiological responses-variation that remains poorly understood but is critical for safe and effective translation to humans. We applied a 2 days per week intermittent fasting (IF) regimen to 10 inbred strains from the Collaborative...

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PMID: 41701627
DOI: 10.1093/genetics/iyag045
PMCID: PMC13147523

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