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Article

Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse.

Psychoneuroendocrinology - 1 Feb 2022

Almeida Daniel, Fiori Laura M, Chen Gary G, Aouabed Zahia, Lutz Pierre-Eric, Zhang Tie-Yuan, Mechawar Naguib, Meaney Michael J, Turecki Gustavo

Abstract excerpt

Childhood abuse significantly increases the lifetime risk of negative mental health outcomes. The oxytocinergic system, which plays a role in complex social and emotional behaviors, has been shown to be sensitive to early-life experiences. While previous studies have investigated the relationship between early-life adversity and oxytocin, they did so with peripheral samples. We, therefore, aimed to characterize...

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Identifiers

PMID: 34839083
DOI: 10.1016/j.psyneuen.2021.105600

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