Article
Whole-exome sequencing reveals novel candidate single nucleotide variations for preventing adverse effects of levonorgestrel implantation.
Pharmacogenomics - 1 Dec 2021
Zhu Weiqiang, Zhang Junxian, Yuan Xuelian, Liu Xiaoli, Zhang Zhaofeng, Mao Yanyan, Feng Ying, Yue Ailing, Sun Junjie, Wen Chuan, Xu Jianhua, Shen Yupei, Che Yan, Du Jing
Abstract excerpt
Aim: To identify novel genes associated with adverse effects of levonorgestrel (LNG) implants based on comparative whole-exome sequencing. Materials & methods: A cohort comprising 104 participants, including 52 controls and 52 women with LNG-related adverse effects, was recruited. Seven cases and eight controls were selected for whole-exome sequencing. We verified 13 single nucleotide variations (SNVs) related...
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