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Article

Relevance of BRAF Subcellular Localization and Its Interaction with KRAS and KIT Mutations in Skin Melanoma.

International journal of molecular sciences - 3 Nov 2021

Beleaua Marius-Alexandru, Jung Ioan, Braicu Cornelia, Milutin Doina, Gurzu Simona

Abstract excerpt

Although skin melanoma (SKM) represents only one-quarter of newly diagnosed skin malignant tumors, it presents a high mortality rate. Hence, new prognostic and therapeutic tools need to be developed. This study focused on investigating the prognostic value of the subcellular expression of BRAF, KRAS, and KIT in SKM in correlation with their gene-encoding interactions. In silico analysis of the abovementioned gene...

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Identifiers

PMID: 34769348
DOI: 10.3390/ijms222111918
PMCID: PMC8584522

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