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Article

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

Journal of the International AIDS Society - 1 Nov 2021

Parikh Urvi M, Penrose Kerri J, Heaps Amy L, Halvas Elias K, Goetz B Jay, Gordon Kelley C, Hardesty Russell, Sethi Rahil, Schwarzmann William, Szydlo Daniel W, Husnik Marla J, Chandran Uma, Palanee-Phillips Thesla, Baeten Jared M, Mellors John W

Abstract excerpt

INTRODUCTION: A potential concern with the use of dapivirine (DPV) for HIV prevention is the selection of a drug-resistant virus that could spread and reduce the effectiveness of non-nucleoside reverse transcriptase (NNRTI)-based first-line antiretroviral therapy. We evaluated HIV-1 seroconversions in MTN-020/ASPIRE for selection of drug resistance and evaluated the genetic basis for observed reductions in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34762770
DOI: 10.1002/jia2.25833
PMCID: PMC8583424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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