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Symmetry breaking in the female germline cyst

11 Nov 2021

Abstract excerpt

oocyte and is required for oocyte specification. The spectraplakin Shot recruits Patronin to the fusome, a branched structure extending into all cyst cells. Patronin stabilizes more MTs in the cell with the most fusome material. Our data suggest that this weak asymmetry is amplified by Dynein-dependent transport of Patronin-stabilized MTs. This forms a polarized MT network, along which Dynein transports oocyte...

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PMID: 34762476
DOI: 10.1126/science.abj3125

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