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Article

The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2022

Lee Jessica K, Hazar-Rethinam Mehlika, Decker Brennan, Gjoerup Ole, Madison Russell W, Lieber Daniel S, Chung Jon H, Schrock Alexa B, Creeden James, Venstrom Jeffrey, Alexander Brian, Oxnard Geoffrey R

Abstract excerpt

PURPOSE: Oncogenic kinase fusions are targetable with approved and investigational therapies and can also mediate acquired resistance (AR) to targeted therapy. We aimed to understand the clinical validity of liquid biopsy comprehensive genomic profiling (CGP) to detect kinase fusions pan tumor. EXPERIMENTAL DESIGN: CGP was performed on plasma and tissue samples during clinical care. All exons plus selected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34753780
DOI: 10.1158/1078-0432.CCR-21-2136
PMCID: PMC9377769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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