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Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool

4 Nov 2021

Abstract excerpt

Skeletal muscle stem cells, i.e., satellite cells (SCs), are the essential source of new myonuclei for skeletal muscle regeneration following injury or chronic degenerative myopathies. Both SC number and regenerative capacity diminish during aging. However, molecular regulators that govern sizing of the initial SC pool are unknown. We demonstrate that fibroblast growth factor 6 (FGF6) is critical for SC pool...

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PMID: 34739848
DOI: 10.1016/j.stemcr.2021.10.006

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