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Novel suction-based in vivo cutaneous DNA transfection platform

5 Nov 2021

Abstract excerpt

This work reports a suction-based cutaneous delivery method for in vivo DNA transfection. Following intradermal Mantoux injection of plasmid DNA in a rat model, a moderate negative pressure is applied to the injection site, a technique similar to Chinese báguàn and Middle Eastern hijama cupping therapies. Strong GFP expression was demonstrated with pEGFP-N1 plasmids where fluorescence was observed as early as 1...

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PMID: 34739313
DOI: 10.1126/sciadv.abj0611

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