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TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction

4 Nov 2021

Abstract excerpt

p16 inhibits cyclin-dependent kinases and regulates senescence-mediated arrest as well as p21. Nuclear p16 promotes G1 cell cycle arrest and cellular senescence. In various glomerular diseases, nuclear p16 expression is associated with disease progression. Therefore, the location of p16 is important. However, the mechanism of p16 trafficking between the nucleus and cytoplasm is yet to be fully investigated....

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PMID: 34737348
DOI: 10.1038/s41598-021-01150-4

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