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Article

miR-497-5p/SALL4 axis promotes stemness phenotype of choriocarcinoma and forms a feedback loop with DNMT-mediated epigenetic regulation.

Cell death & disease - 3 Nov 2021

Peng Zheng, Zhang Yi, Shi Dazun, Jia Yanyan, Shi Huirong, Liu Huining

Abstract excerpt

Choriocarcinoma stem-like cells (CSLCs) might be at the origin of choriocarcinoma development associated with drug resistance or relapse. Spalt-like transcription factor 4 (SALL4), which is considered to be a stemness-related gene, can be regulated by miRNAs. In this study, SALL4 result is associated with progression-free survival of choriocarcinoma patients and CSLC's stemness characteristics. In addition, it...

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Identifiers

PMID: 34732693
DOI: 10.1038/s41419-021-04315-1
PMCID: PMC8566582

Genes

SALL4

Provenance

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