Article
RNAseq-based gene expression profiling of the Anopheles funestus pyrethroid-resistant strain FUMOZ highlights the predominant role of the duplicated CYP6P9a/b cytochrome P450s.
G3 (Bethesda, Md.) - 4 Jan 2022
Wondji Charles S, Hearn Jack, Irving Helen, Wondji Murielle J, Weedall Gareth
Abstract excerpt
Insecticide-based interventions, notably long-lasting insecticidal nets, against mosquito vectors of malaria are currently threatened by pyrethroid resistance. Here, we contrasted RNAseq-based gene expression profiling of laboratory-resistant (FUMOZ) and susceptible (FANG) strains of the major malaria vector Anopheles funestus. Cytochrome P450 genes were the predominant over-expressed detoxification genes in...
Topics
- Animals
- Anopheles
- Cytochrome P-450 Enzyme System
- Gene Expression Profiling
- Insecticide Resistance
- Insecticides
- Malaria
- Mosquito Vectors
- Polymorphism, Single Nucleotide
- Pyrethrins