Article
Mutational analysis of TlyA from Brachyspira hampsonii reveals two key residues conserved in pathogenic bacteria responsible for oligomerization and hemolytic activity.
Biochimica et biophysica acta. General subjects - 1 Feb 2022
Keith Brandon A, Harding John C S, Loewen Matthew E
Abstract excerpt
BACKGROUND: TlyA proteins are expressed in a variety of pathogenic bacteria and possess dual hemolytic and ribosomal RNA methyltransferase functions. While the mechanism of TlyA mediated rRNA methylation is well understood, relatively little is known about the mechanism of TlyA induced hemolysis. METHODS: TlyA protein from the pig pathogen Brachyspira hampsonii was heterologously expressed and purified from an E....
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