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Article

Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells.

American journal of respiratory and critical care medicine - 15 Dec 2021

Willis Gareth R, Reis Monica, Gheinani Ali Hashemi, Fernandez-Gonzalez Angeles, Taglauer Elizabeth S, Yeung Vincent, Liu Xianlan, Ericsson Maria, Haas Eric, Mitsialis S Alex, Kourembanas Stella

Abstract excerpt

Rationale: Mesenchymal stem/stromal cell (MSC)-small extracellular vesicle (MEx) treatment has shown promise in experimental models of neonatal lung injury. The molecular mechanisms by which MEx afford beneficial effects remain incompletely understood. Objectives: To investigate the therapeutic mechanism of action through assessment of MEx biodistribution and impact on immune cell phenotypic heterogeneity....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34699335
DOI: 10.1164/rccm.202102-0329OC
PMCID: PMC8865710

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