Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional Regulation of GDF15 by EGR1 Promotes Head and Neck Cancer Progression through a Positive Feedback Loop

15 Oct 2021

Abstract excerpt

Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β (TGF-β) superfamily, has been reported to be overexpressed in different kinds of cancer types. However, the function and mechanism of GDF15 in head and neck cancer (HNC) remains unclear. The Cancer Genome Atlas (TCGA) data show that the expression of GDF15 is significantly associated with tumor AJCC stage, lymph...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GDF15 and Related Biomarkers
Share to Nuclear Receptors and Signaling
Share to Nutrition and Health in Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34681812
DOI: 10.3390/ijms222011151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Regulation of GDF15 by EGR1 Promotes Head and Neck Cancer Progression through a Positive Feedback LoopPMID 34681812Read ↗

Pan-cancer characterization of GDF15 as a potential prognosis and immunological biomarkerSemantic proximity Read ↗

Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion and tumorigenesis in bladder carcinoma cellsSemantic proximity Read ↗

EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung CancerSemantic proximity Read ↗

GDF-15: A Multifunctional Modulator and Potential Therapeutic Target in CancerSemantic proximity Read ↗

GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathwaySemantic proximity Read ↗

Evaluation of GDF15 Significance as a Biomarker in Laryngeal Squamous Cell CarcinomaSemantic proximity Read ↗

Mapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer typesSemantic proximity Read ↗

GDF15 and Growth ControlSemantic proximity Read ↗

Control of glioma cell migration and invasiveness by GDF-15Semantic proximity Read ↗

Utility of GDF ‐15 as a diagnostic biomarker in gastric cancer: an investigation combining GEO , TCGA and meta‐analysisSemantic proximity Read ↗

A Multi-Omics Analysis of the Prognostic Biomarker GDF15 Associated with Immune Infiltration and Regulated Mitochondrial-Dependent Apoptosis in Colorectal CancerSemantic proximity Read ↗

GDF15 promotes glioma stem cell-like phenotype via regulation of ERK1/2–c-Fos–LIF signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.