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Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery

30 Sept 2021

Abstract excerpt

Prime editing is a recent precision genome editing modality whose versatility offers the prospect for a wide range of applications, including the development of targeted genetic therapies. Yet, an outstanding bottleneck for its optimization and use concerns the difficulty in delivering large prime editing complexes into cells. Here, we demonstrate that packaging prime editing constructs in adenoviral capsids...

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PMID: 34669958
DOI: 10.1093/nar/gkab938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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