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Article

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.

Nature immunology - 1 Feb 2022

Andreakos Evangelos, Abel Laurent, Vinh Donald C, Kaja Elżbieta, Drolet Beth A, Zhang Qian, O'Farrelly Cliona, Novelli Giuseppe, Rodríguez-Gallego Carlos, Haerynck Filomeen, Prando Carolina, Pujol Aurora, Su Helen C, Casanova Jean-Laurent, Spaan András N

Abstract excerpt

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown....

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Identifiers

PMID: 34667308
DOI: 10.1038/s41590-021-01030-z
PMCID: PMC8524403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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