Article
Co-evolutionary Signals Identify Burkholderia pseudomallei Survival Strategies in a Hostile Environment.
Molecular biology and evolution - 7 Jan 2022
Chewapreecha Claire, Pensar Johan, Chattagul Supaksorn, Pesonen Maiju, Sangphukieo Apiwat, Boonklang Phumrapee, Potisap Chotima, Koosakulnirand Sirikamon, Feil Edward J, Dunachie Susanna, Chantratita Narisara, Limmathurotsakul Direk, Peacock Sharon J, Day Nick P J, Parkhill Julian, Thomson Nicholas R, Sermswan Rasana W, Corander Jukka
Abstract excerpt
The soil bacterium Burkholderia pseudomallei is the causative agent of melioidosis and a significant cause of human morbidity and mortality in many tropical and subtropical countries. The species notoriously survives harsh environmental conditions but the genetic architecture for these adaptations remains unclear. Here we employed a powerful combination of genome-wide epistasis and co-selection studies (2,011...
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