Article
Integrative genomic, transcriptional, and proteomic diversity in natural isolates of the human pathogen Burkholderia pseudomallei.
Journal of bacteriology - 1 Jun 2005
Ou Keli, Ong Catherine, Koh Shze Yung, Rodrigues Fiona, Sim Siew Hoon, Wong Daniel, Ooi Chia Huey, Ng Kim Chong, Jikuya Hiroyuki, Yau Chin Chin, Soon Sou Yen, Kesuma Djohan, Lee May Ann, Tan Patrick
Abstract excerpt
Natural isolates of pathogenic bacteria can exhibit a broad range of phenotypic traits. To investigate the molecular mechanisms contributing to such phenotypic variability, we compared the genomes, transcriptomes, and proteomes of two natural isolates of the gram-negative bacterium Burkholderia pseudomallei, the causative agent of the human disease melioidosis. Significant intrinsic genomic, transcriptional, and...
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