Article
REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir.
Cancer epidemiology - 1 Dec 2021
Jamwal Rajeshwer Singh, Mahajan Nikita, Bhat Gh Rasool, Bhat Amrita, Shah Ruchi, Verma Sonali, Sharma Minerva, Sharma Bhawani, Qadri Raies A, Kumar Rakesh, Bhat Audesh
Abstract excerpt
BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common lung cancer, accounting for 80-85% of all lung cancer cases. Various genetic studies have associated REV3L (Protein reversion less 3-like) gene mutations, which encodes the catalytic subunit of error prone translesion synthesis polymerase zeta with cancer, including lung cancer; however, no such data is available from any North Indian population....
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