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Article

Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants.

Journal of the American College of Cardiology - 19 Oct 2021

Zhang Zhong-He, Barajas-Martínez Hector, Xia Hao, Li Bian, Capra John A, Clatot Jerome, Chen Gan-Xiao, Chen Xiu, Yang Bo, Jiang Hong, Tse Gary, Aizawa Yoshiyasu, Gollob Michael H, Scheinman Melvin, Antzelevitch Charles, Hu Dan

Abstract excerpt

BACKGROUND: Two major forms of inherited J-wave syndrome (JWS) are recognized: early repolarization syndrome (ERS) and Brugada syndrome (BrS). OBJECTIVES: This study sought to assess the distinct features between patients with ERS and BrS carrying pathogenic variants in SCN5A. METHODS: Clinical evaluation and next-generation sequencing were performed in 262 probands with BrS and 104 with ERS. Nav1.5 and Kv4.3...

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Identifiers

PMID: 34649698
DOI: 10.1016/j.jacc.2021.08.024
PMCID: PMC9272763

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