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The Feasibility of Using Biomarkers Derived from Circulating Tumor DNA Sequencing as Predictive Classifiers in Patients with Small-Cell Lung Cancer.

Cancer research and treatment - 1 Jul 2022

Feng Yu, Liu Yutao, Yuan Mingming, Dong Guilan, Zhang Hongxia, Zhang Tongmei, Chang Lianpeng, Xia Xuefeng, Li Lifeng, Zhu Haohua, Xing Puyuan, Wang Hongyu, Shi Yuankai, Wang Zhijie, Hu Xingsheng

Abstract excerpt

PURPOSE: To investigate the feasibility of biomarkers based on dynamic circulating tumor DNA (ctDNA) to classify small cell lung cancer (SCLC) into different subtypes. MATERIALS AND METHODS: Tumor and longitudinal plasma ctDNA samples were analyzed by next-generation sequencing of 1,021 genes. PyClone was used to infer the molecular tumor burden index (mTBI). Pre-treatment tumor tissues [T1] and serial plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34645133
DOI: 10.4143/crt.2021.905
PMCID: PMC9296939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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