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Article

Sex-specific effects of polygenic risk for schizophrenia on lifespan cognitive functioning in healthy individuals.

Translational psychiatry - 11 Oct 2021

Koch Elise, Nyberg Lars, Lundquist Anders, Pudas Sara, Adolfsson Rolf, Kauppi Karolina

Abstract excerpt

Polygenic risk for schizophrenia has been associated with lower cognitive ability and age-related cognitive change in healthy individuals. Despite well-established neuropsychological sex differences in schizophrenia patients, genetic studies on sex differences in schizophrenia in relation to cognitive phenotypes are scarce. Here, we investigated whether the effect of a polygenic risk score (PRS) for schizophrenia...

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Identifiers

PMID: 34635642
DOI: 10.1038/s41398-021-01649-4
PMCID: PMC8505489

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