Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.

Molecular brain - 11 Oct 2021

Foliaki Simote T, Schwarz Benjamin, Groveman Bradley R, Walters Ryan O, Ferreira Natalia C, Orrù Christina D, Smith Anna, Wood Aleksandar, Schmit Olivia M, Freitag Phoebe, Yuan Jue, Zou Wenquan, Bosio Catharine M, Carroll James A, Haigh Cathryn L

Abstract excerpt

The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals with confirmed genetic mutations including PRNPE200K, trisomy 21 (T21), and LRRK2G2019S, which are associated with Creutzfeldt Jakob disease, Down Syndrome, and Parkinson's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creutzfeldt-Jakob Syndrome
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Nerve Net

Share to Neurotransmitter Agents

Share to Organoids

Share to Prion Proteins

Share to Receptors, Neurotransmitter

Source

Open in PubMed Open full text

Identifiers

PMID: 34635127
DOI: 10.1186/s13041-021-00864-w
PMCID: PMC8507222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases.PMID 34635127Read ↗

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical OrganoidsSemantic proximity Read ↗

Epileptic Encephalopathies as Neurodegenerative Disorders.Semantic proximity Read ↗

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoidsSemantic proximity Read ↗

Cerebral Cortical-Like Organoid Model of PPP2R5D Induced Genetic Intellectual Disability Displays Variant-Specific Disease Severity PhenotypeSemantic proximity Read ↗

Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced NeuronsSemantic proximity Read ↗

Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles.Semantic proximity Read ↗

Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries SyndromeSemantic proximity Read ↗

Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.Semantic proximity Read ↗

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read ↗

Differences between Cerebral Organoids Derived from a non-PD and a Parkinson’s Patient: A Potential Vulnerability for Neuroinvasive VirusesSemantic proximity Read ↗

Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes.Semantic proximity Read ↗

Identification of neural oscillations and epileptiform changes in human brain organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.