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Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

7 Oct 2021

Abstract excerpt

Common variable immunodeficiency (CVID) is characterized by profound primary antibody defects and frequent infections, yet autoimmune/inflammatory complications of unclear origin occur in 50% of individuals and lead to increased mortality. Here, we show that circulating bacterial 16S rDNA belonging to gut commensals was significantly increased in CVID serum (P < 0.0001), especially in patients with inflammatory...

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PMID: 34622805
DOI: 10.1172/jci.insight.144777

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