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Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

5 Oct 2021

Abstract excerpt

Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-characterized P. vivax parasites that are safe and suitable for use in modern CHMI models are limited. Here, 2 healthy malaria-naive United Kingdom adults with universal...

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PMID: 34609964
DOI: 10.1172/jci.insight.152465

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