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Article

Filamin-C variant-associated cardiomyopathy: A pooled analysis of individual patient data to evaluate the clinical profile and risk of sudden cardiac death.

Heart rhythm - 1 Feb 2022

Celeghin Rudy, Cipriani Alberto, Bariani Riccardo, Bueno Marinas Maria, Cason Marco, Bevilacqua Michela, De Gaspari Monica, Rizzo Stefania, Rigato Ilaria, Da Pozzo Stefano, Zorzi Alessandro, Perazzolo Marra Martina, Thiene Gaetano, Iliceto Sabino, Basso Cristina, Corrado Domenico, Pilichou Kalliopi, Bauce Barbara

Abstract excerpt

BACKGROUND: Mutations in filamin-C (FLNC) are involved in the pathogenesis of arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM), and have been associated with a left ventricular (LV) phenotype, characterized by nonischemic LV fibrosis, ventricular arrhythmias, and sudden cardiac death (SCD). OBJECTIVE: The purpose of this study was to investigate the prevalence of FLNC variants in a...

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Identifiers

PMID: 34601126
DOI: 10.1016/j.hrthm.2021.09.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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