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Article

Synergistic cytotoxicity of the CDK4 inhibitor Fascaplysin in combination with EGFR inhibitor Afatinib against Non-small Cell Lung Cancer.

Investigational new drugs - 1 Apr 2022

Plangger Adelina, Rath Barbara, Hochmair Maximilian, Funovics Martin, Neumayer Christoph, Zeillinger Robert, Hamilton Gerhard

Abstract excerpt

In the absence of suitable molecular markers, non-small cell lung cancer (NSCLC) patients have to be treated with chemotherapy with poor results at advanced stages. Therefore, the activity of the anticancer marine drug fascaplysin was tested against primary NSCLC cell lines established from pleural effusions. Cytotoxicity of the drug or combinations were determined using MTT assays and changes in intracellular...

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Identifiers

PMID: 34596822
DOI: 10.1007/s10637-021-01181-8
PMCID: PMC8993745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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