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Article

GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.

Frontiers in immunology - 1 Jan 2021

Ming Siqi, Yin Huan, Li Xingyu, Gong Sitang, Zhang Guoliang, Wu Yongjian

Abstract excerpt

Gastric CD4+T cells contribute to Helicobacter pylori (H. pylori)-induced gastritis by amplifying mucosal inflammation and exacerbating mucosal injuries. However, the pathogenic CD4+ T cell subset involved in gastritis and the potential regulators are still unclear. Here we identified an IL-21-producing gastric CD4+T cell subset, which exhibited tissue-resident CXCR5-BTLA-PD-1hi TFH-like phenotype in H....

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Identifiers

PMID: 34589088
DOI: 10.3389/fimmu.2021.736269
PMCID: PMC8475268

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