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Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

29 Sept 2021

Abstract excerpt

Parkinson's disease (PD) is a chronic neurological disorder associated with the misfolding of alpha-synuclein (α-syn) into aggregates within nerve cells that contribute to their neurodegeneration. Recent evidence suggests α-syn aggregation may begin in the gut and travel to the brain along the vagus nerve, with microbes potentially a trigger initiating α-syn misfolding. However, the effects α-syn alterations on...

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PMID: 34588600
DOI: 10.1038/s42003-021-02666-1

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