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Article

Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer.

BMC cancer - 29 Sept 2021

Huang Chia-Chen, Lai Chung-Yu, Tsai Chin-Hung, Wang Jiun-Yao, Wong Ruey-Hong

Abstract excerpt

BACKGROUND: Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor genes. Tea polyphenols may inhibit DNMT activity. We designed a case-control study to evaluate the combined effects of smoking, green tea consumption, DNMT3B - 149 polymorphism, and DNA damage...

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Identifiers

PMID: 34587932
DOI: 10.1186/s12885-021-08800-w
PMCID: PMC8480053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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