From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques.

doi:10.3390/ijms221810065

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Article

From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques.

International journal of molecular sciences - 17 Sept 2021

Balla Beata, Tripon Florin, Banescu Claudia

Abstract excerpt

Genome engineering makes the precise manipulation of DNA sequences possible in a cell. Therefore, it is essential for understanding gene function. Meganucleases were the start of genome engineering, and it continued with the discovery of Zinc finger nucleases (ZFNs), followed by Transcription activator-like effector nucleases (TALENs). They can generate double-strand breaks at a desired target site in the genome,...

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PMID: 34576226
DOI: 10.3390/ijms221810065
PMCID: PMC8470190

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