Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of a Rare Fungal PKS CgPKS11 Promotes Chaetoglobosin A Biosynthesis, Yet Defers the Growth and Development of Chaetomium globosum

13 Sept 2021

Abstract excerpt

We previously reported that chaetoglobosin A (ChA) exhibits a great potential in the biocontrol of nematodes and pathogenic fungi. To improve the production of ChA, a CRISPR-Cas9 system was created and applied for eliminating potential competitive polyketide products. One of the polyketide synthase encoding genes, Cgpks11, which is putatively involved in the biosynthesis of chaetoglocin A, was disrupted. Cgpks11...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungal Biology and Applications
Share to Microbial Natural Products and Biosynthesis
Share to Plant Pathogens and Fungal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34575788
DOI: 10.3390/jof7090750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of a Rare Fungal PKS CgPKS11 Promotes Chaetoglobosin A Biosynthesis, Yet Defers the Growth and Development of Chaetomium globosumPMID 34575788Read ↗

Functional analysis of a chaetoglobosin A biosynthetic regulator in Chaetomium globosumSemantic proximity Read ↗

Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A ReviewSemantic proximity Read ↗

CgVeA, a light signaling responsive regulator, is involved in regulation of chaetoglobosin A biosynthesis and conidia development in Chaetomium globosumSemantic proximity Read ↗

A Dual-Plasmid CRISPR/Cas System for Mycotoxin Elimination in Polykaryotic Industrial FungiSemantic proximity Read ↗

Efficient disruption of CmHk1 using CRISPR/Cas9 ribonucleoprotein delivery in Cordyceps militaris.Semantic proximity Read ↗

RNA-Seq-Based Transcriptomic Analysis of Saccharopolyspora spinosa Revealed the Critical Function of PEP Phosphonomutase in the Replenishment Pathway.Semantic proximity Read ↗

Transcription Factor CgSte12 Regulates Pathogenicity by Affecting Appressorium Structural Development in the Anthracnose-Causing Fungus Colletotrichum gloeosporioides.Semantic proximity Read ↗

CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicumSemantic proximity Read ↗

Efficient multiple gene knock-out in <i>Colletotrichum higginsianum</i> via CRISPR-Cas9 ribonucleoprotein and <i>URA3</i> -based marker recyclingSemantic proximity Read ↗

Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system.Semantic proximity Read ↗

Establishment of CRISPR/Cas9 in Alternaria alternata.Semantic proximity Read ↗

PsGRGH, a TOS1 family-like gene, is involved in the vegetative growth, environmental stress response, and pathogenicity of Phytophthora sojaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.