Article
Evidence That HFE H63D Variant Is a Potential Disease Modifier in Cluster Headache.
Journal of molecular neuroscience : MN - 1 Feb 2022
Papasavva Maria, Vikelis Michail, Katsarou Martha-Spyridoula, Siokas Vasileios, Dermitzakis Emmanouil, Papademetriou Christoforos, Karakostis Konstantinos, Lazopoulos George, Dardiotis Efthimios, Drakoulis Nikolaos
Abstract excerpt
Cluster headache (CH) is a primary headache disorder with a complex genetic background. Several studies indicate a potential link between iron homeostasis and the pathophysiology of primary headaches. The HFE gene encodes for a protein involved in iron metabolism, while genetic variants in HFE have been associated with hereditary hemochromatosis (HH), an iron overload disorder. The objective of the current study...
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