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Article

Molecular Genetics, Clinical Characteristics, and Treatment Outcomes of KATP-Channel Neonatal Diabetes Mellitus in Vietnam National Children's Hospital.

Frontiers in endocrinology - 1 Jan 2021

Ngoc Can Thi Bich, Dien Tran Minh, De Franco Elisa, Ellard Sian, Houghton Jayne A L, Lan Nguyen Ngoc, Thao Bui Phuong, Khanh Nguyen Ngoc, Flanagan Sarah E, Craig Maria E, Dung Vu Chi

Abstract excerpt

Background: Neonatal diabetes mellitus (NDM) is defined as insulin-requiring persistent hyperglycemia occurring within the first 6 months of life, which can result from mutations in at least 25 different genes. Activating heterozygous mutations in genes encoding either of the subunits of the ATP-sensitive K+ channel (KATP channel; KCNJ11 or ABCC8) of the pancreatic beta cell are the most common cause of permanent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34566892
DOI: 10.3389/fendo.2021.727083
PMCID: PMC8458931

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