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Article

Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3.

Neurobiology of disease - 1 Dec 2021

Johnson Sean L, Libohova Kozeta, Blount Jessica R, Sujkowski Alyson L, Prifti Matthew V, Tsou Wei-Ling, Todi Sokol V

Abstract excerpt

Of the family of polyglutamine (polyQ) neurodegenerative diseases, Spinocerebellar Ataxia Type 3 (SCA3) is the most common. Like other polyQ diseases, SCA3 stems from abnormal expansions in the CAG triplet repeat of its disease gene resulting in elongated polyQ repeats within its protein, ataxin-3. Various ataxin-3 protein domains contribute to its toxicity, including the valosin-containing protein (VCP)-binding...

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Identifiers

PMID: 34563642
DOI: 10.1016/j.nbd.2021.105516
PMCID: PMC8693084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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