Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

23 Sept 2021

Abstract excerpt

Abstract Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450 (CYP) to detoxify or activate such carcinogens. In this study, CYP1A1, CYP1B1 and CYP2W1 expression in HNC was correlated with potential as target for duocarmycin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Treatments and Mutations
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34556703
DOI: 10.1038/s41598-021-98217-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancerPMID 34556703Read ↗

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs.Semantic proximity Read ↗

Cytochrome P450 gene polymorphism and cancer.Semantic proximity Read ↗

Association of cytochrome P450 1B1 haplotypes with head and neck cancer risk.Semantic proximity Read ↗

CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathwaySemantic proximity Read ↗

Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.Semantic proximity Read ↗

Expression of xenobiotic metabolizing genes in head and neck cancer tissues.Semantic proximity Read ↗

Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.Semantic proximity Read ↗

Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.Semantic proximity Read ↗

Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients.Semantic proximity Read ↗

Cytochrome P450 2W1 (CYP2W1) in Colorectal CancersSemantic proximity Read ↗

Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.Semantic proximity Read ↗

Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.