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MCM9 is associated with germline predisposition to early-onset cancer—clinical evidence

23 Sept 2021

Abstract excerpt

Mutated MCM9 has been associated with primary ovarian insufficiency. Although MCM9 plays a role in genome maintenance and has been reported as a candidate gene in a few patients with inherited colorectal cancer (CRC), it has not been clearly established as a cancer predisposition gene. We re-evaluated family members with MCM9-associated fertility problems. The heterozygote parents had a few colonic polys. Three...

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PMID: 34556653
DOI: 10.1038/s41525-021-00242-4

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