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Article

Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy

1 Sept 2021

Abstract excerpt

The exon-52-deleted mdx52 mouse is a critical model of Duchenne muscular dystrophy (DMD), as it features a deletion in a hotspot region of the DMD gene, frequently mutated in patients. Deletion of exon 52 impedes expression of several brain dystrophins (Dp427, Dp260 and Dp140), thus providing a key model for studying the cognitive impairment associated with DMD and testing rescuing strategies. Here, using in vivo...

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PMID: 34546327
DOI: 10.1242/dmm.049028

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