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Article

Validation of DE50-MD dogs as a model for the brain phenotype of Duchenne muscular dystrophy.

Disease models & mechanisms - 1 Mar 2022

Crawford Abbe H, Hildyard John C W, Rushing Sophie A M, Wells Dominic J, Diez-Leon Maria, Piercy Richard J

Abstract excerpt

Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disease, is associated with neurodevelopmental disorders and cognitive impairment caused by brain dystrophin deficiency. Dog models of DMD represent key translational tools to study dystrophin biology and to develop novel therapeutics. However, characterisation of dystrophin expression and function in the canine brain is lacking. We studied the DE50-MD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35019137
DOI: 10.1242/dmm.049291
PMCID: PMC8906169

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