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Article

Cetuximab-siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib.

Technology in cancer research & treatment - 1 Jan 2000

Sreedurgalakshmi K, Srikar R, Harikrishnan K, Srinivasan Lakshmi, Rajkumari Reena

Abstract excerpt

Delivery of small-interfering RNA (siRNA) has been of great interest in the past decade for effective gene silencing. To overcome synthetic and regulatory challenges posed by nanoparticle-mediated siRNA delivery, antibody-siRNA conjugate (ARC) platform is emerging as a potential siRNA delivery system suitable for clinical translation. Herein, we have developed a delivery technology based on the ARC platform for...

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PMID: 34542333
DOI: 10.1177/15330338211041453
PMCID: PMC8461128

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