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Article

Extracellular vesicles synchronize cellular phenotypes of differentiating cells.

Journal of extracellular vesicles - 1 Sept 2021

Minakawa Tomohiro, Matoba Tetsuya, Ishidate Fumiyoshi, Fujiwara Takahiro K, Takehana Sho, Tabata Yasuhiko, Yamashita Jun K

Abstract excerpt

During embryonic development, cells differentiate in a coordinated manner, aligning their fate decisions and differentiation stages with those of surrounding cells. However, little is known about the mechanisms that regulate this synchrony. Here we show that cells in close proximity synchronize their differentiation stages and cellular phenotypes with each other via extracellular vesicle (EV)-mediated cellular...

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Identifiers

PMID: 34533283
DOI: 10.1002/jev2.12147
PMCID: PMC8447227

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