Article
Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice.
G3 (Bethesda, Md.) - 19 Oct 2021
Lobo Alexandra K, Traeger Lindsay L, Keller Mark P, Attie Alan D, Rey Federico E, Broman Karl W
Abstract excerpt
In a Diversity Outbred mouse project with genotype data on 500 mice, including 297 with microbiome data, we identified three sets of sample mix-ups (two pairs and one trio) as well as at least 15 microbiome samples that appear to be mixtures of pairs of mice. The microbiome data consisted of shotgun sequencing reads from fecal DNA, used to characterize the gut microbial communities present in these mice. These...
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