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Article

Estimating the influence of body mass index (BMI) on mortality using offspring BMI as an instrumental variable.

International journal of obesity (2005) - 1 Jan 2022

Hyppönen Elina, Carslake David, Berry Diane J, Power Chris, Davey Smith George

Abstract excerpt

OBJECTIVE: High body mass index (BMI) is an important predictor of mortality but estimating underlying causality is hampered by confounding and pre-existing disease. Here, we use information from the offspring to approximate parental BMIs, with an aim to avoid biased estimation of mortality risk caused by reverse causality. METHODS: The analyses were based on information on 9674 offspring-mother and 9096...

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Identifiers

PMID: 34497352
DOI: 10.1038/s41366-021-00962-8
PMCID: PMC7612209

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