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Article

A novel activating JAK1 mutation in chronic eosinophilic leukemia.

Blood advances - 28 Sept 2021

Shomali William, Damnernsawad Alisa, Theparee Talent, Sampson David, Morrow Quinlan, Yang Fei, Fernandez-Pol Sebastian, Press Richard, Zehnder James, Tyner Jeffrey W, Gotlib Jason

Abstract excerpt

Hypereosinophilia (HE) has been defined as persistent eosinophilia >1.5 × 109/L; it is broadly divided into primary HE (clonal or neoplastic; HEN), secondary/reactive HE (HER), or HE of undetermined significance (HEUS) when no cause is identified. The use of myeloid next-generation sequencing (NGS) panels has led to the detection of several mutations in patients previously diagnosed with HEUS, reassigning some...

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Source

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Identifiers

PMID: 34496019
DOI: 10.1182/bloodadvances.2021004237
PMCID: PMC8945578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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