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Article

Understanding the role of R266K mutation in cystathionine β-synthase (CBS) enzyme: an in silico study.

Journal of biomolecular structure & dynamics - 1 Jan 2022

Bhatt Aashish, Ali Md Ehesan

Abstract excerpt

Human cystathionine β-synthase (hCBS) is a Heme-containing, unique pyridoxal 5'-phosphate (PLP) dependent enzyme. CBS catalyzes the bio-chemical condensation reactions in the transsulfuration pathway. The role of Heme in the catalytic activities of the hCBS enzyme is still unknown, even though various experimental studies indicated its participation in the bi-directional electronic communication with the PLP...

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PMID: 34495791
DOI: 10.1080/07391102.2021.1975564

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