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Gene interfered-ferroptosis therapy for cancers

7 Sept 2021

Abstract excerpt

Although some effective therapies have been available for cancer, it still poses a great threat to human health and life due to its drug resistance and low response in patients. Here, we develop a ferroptosis-based therapy by combining iron nanoparticles and cancer-specific gene interference. The expression of two iron metabolic genes (FPN and LCN2) was selectively knocked down in cancer cells by Cas13a or...

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PMID: 34493724
DOI: 10.1038/s41467-021-25632-1

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