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Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

31 Aug 2021

Abstract excerpt

Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for male fertility in mice and humans. In mice, ex vivo studies of dormant, caudal epididymal sperm demonstrated that sAC is required for initiating capacitation and activating motility. We now use an improved sAC inhibitor, TDI-10229, for a comprehensive analysis of sAC function in mouse and human sperm. In contrast to caudal...

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PMID: 34463764
DOI: 10.1093/molehr/gaab054

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