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SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells

27 Aug 2021

Abstract excerpt

Abstract Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural crest (NC), and mutation of SOX10 in humans may lead to type 4 Waardenburg syndrome (WS). However, the exact role of SOX10 in human NC development and the underlying molecular mechanisms of SOX10-related human diseases remain poorly understood...

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PMID: 34453037
DOI: 10.1038/s41419-021-04099-4

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